The polynucleotide which the region uniqueness which consists of the polypeptide below it rearranges and the cord/code it does the enzyme:(1) arrangement number 2 or the polypeptide which consists of the amino acid arrangement which is shown in arrangement number 8One or several amino acids, being the polypeptide which consists of the amino acid arrangement which deficiency, it is substituted or is inserted, or (2) arrangement number 2 or at the time of amino acid arranging which is shown in arrangement number 8, the polypeptide which (1) the region uniqueness of the polypeptide it rearranges and possesses enzyme activity Or,(3) arrangement number 2 or being the polypeptide which consists of the amino acid arrangement which is shown in arrangement number 8 and the amino acid arrangement which possesses homology of 70% or more, the polypeptide which (1) the region uniqueness of the polypeptide it rearranges and possesses enzyme activity Or,Being the polypeptide which is recognized (4) arrangement number 2 or by the antibody which recognizes the polypeptide which consists of the amino acid arrangement which is shown in arrangement number 8 uniquely, the polypeptide which (1) the region uniqueness of the polypeptide it rearranges and possesses enzyme activity.以下のポリペプチドから成る部位特異的組換え酵素をコードするポリヌクレオチド:(1)配列番号2又は配列番号8に示されるアミノ酸配列から成るポリペプチド;(2)配列番号2又は配列番号8に示されるアミノ酸配列において一個又は数個のアミノ酸が、欠失、置換又は挿入されたアミノ酸配列から成るポリペプチドであって、(1)のポリペプチドの部位特異的組換え酵素活性を有するポリペプチド;又は、(3)配列番号2又は配列番号8に示されるアミノ酸配列と70%以上の相同性を有するアミノ酸配列から成るポリペプチドであって、(1)のポリペプチドの部位特異的組換え酵素活性を有するポリペプチド;又は、(4)配列番号2又は配列番号8に示されるアミノ酸配列から成るポリペプチドを特異的に認識する抗体によって認識されるポリペプチドであって、(1)のポリペプチドの部位特異的組換え酵素活性を有するポリペプチド。