Refers to compounds of thieno [2,3-b] pyridine of formula (a) wherein R1 is alkyl, aryl, alquenilo, alquinilo, among others 2a and R2B are each h, CN, alkyl, arylalkyl, among others R3 is - COOH, - CN, - CONH2, - C (o nhoh), among others R4 is H, halogen, alkyl, hydroxyl, NS, Other R5 and R6 are taken together to form unsaturated cycloalkyl (c4-c8),Aryl or heterocyclic (c4-c8) 4 to 8 members. Preferred compounds are: [2 - methyl - 4 - (P - tolyl - 6,7-dihydro-5h-cyclopenta [4,5] thieno [2,3-b] pyridin-3-yl] Methyl acetate [2 - methyl - 4 - phenyl - 6,7-dihydro-5h-cyclopenta [4,5] thieno [2,3, - B] pyridin-3-yl] Methyl acetate [2 - methyl - 4 - (4-chlorophenyl) - 6,7-dihydro-5h-cyclopenta [4,5] thieno [2,3-b] pyridin-3-yl] acetate Methyl among others.It also relates to a preparation method and a Pharmaceutical composition. These compounds are inhibitors of HIV Replication is useful in the treatment of HIV infectionsSE REFIERE A COMPUESTOS DERIVADOS DE TIENO[2,3-b]PIRIDINA DE FORMULA (A) DONDE R1 ES ALQUILO, ALQUENILO, ALQUINILO, ARILO, ENTRE OTROS R2a Y R2b SON CADA UNO H, CN, ALQUILO, ARILALQUILO, ENTRE OTROS R3 ES -COOH, -CN, -CONH2, -C(O)NHOH, ENTRE OTROS R4 ES H, HALOGENO, CN, HIDROXILO, ALQUILO, ENTRE OTROS R5 Y R6 SE TOMAN JUNTOS PARA FORMAR CICLOALQUILO(C4-C8) INSATURADO, ARILO(C4-C8) O HETEROCICLO DE 4 A 8 MIEMBROS. SON COMPUESTOS PREFERIDOS: [2-METIL-4-P-TOLIL-6,7-DIHIDRO-5H-CICLOPENTA[4,5]TIENO[2,3-b]PIRIDIN-3-IL]ACETATO DE METILO [2-METIL-4-FENIL-6,7-DIHIDRO-5H-CICLOPENTA[4,5]TIENO[2,3-b]PIRIDIN-3-IL]ACETATO DE METILO [2-METIL-4-(4-CLOROFENIL)-6,7-DIHIDRO-5H-CICLOPENTA[4,5]TIENO[2,3-b]PIRIDIN-3-IL]ACETATO DE METILO ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA REPLICACION DEL VIH SIENDO UTILES EN EL TRATAMIENTO DE INFECCIONES POR VIH
