BERGERON, Phillipe,BURFORD, Kristen,CHOWDHURY, Sultan,DEHNHARDT, Christoph Martin,FOCKEN, Thilo,GRIMWOOD, Michael Edward,HASAN, Abid,LAI, Kwong Wah,LIU, Zhiguo,MCKERRALL, Steven,NGUYEN, Teresa Phuongt
申请号：
PE0004862018
公开号：
PE10032018A1
申请日:
2016.09.27
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
The present Invention relates to Organic Compound of formulas (i) and (ii) (IX): RAA is selected from the group consisting of F, CL, BR, I, - CN,Among others, the ring is a heteroaryl 5-12 members or a heterociclilo 3 - 15 members The Ring B is a carbociclilo 5,6 or 7 members or a heterociclilo 5,6 or 7 members. A1a is H or c1-c4 alkyl r1b is H or c1-c4 alkyl R2 is selected from the group consisting of H, F, CL, R3, among othersR4 and R5 are each independently selected from the group consisting of H, F, BR, CN, among others R6 is selected from the group consisting of H, alkyl C1 - C3 - C8 C8, cycloalkyl, aryl,Among others R7 is selected from the group consisting of C1 to C8 alkyl -, heterociclilo heteroaryl 3 to 15 members, 12 members, among others R8 is selected from the group consisting of H,C1 to C8 alkyl -, aryl, among others R9 is selected from the group consisting alquiloc1 cycloalkyl - C3 - C8 C8 h, among others.Compounds are preferred (S) - 4 - (4,4 - dimethyl - 2 - 1 - fenilpiperidin - yl) methyl) - 2,5 - difluoro - N - (1,2,4 - tiadiazol - 5 - il) benzenesulfonamide 2.5 - difluoro - (4 - ((2S,4R) - phenyl - 2 - 4 - (trifluoromethyl) piperidin-1-yl) methyl) - N - (1,2,4 - tiadiazol - 5 - il) benzenesulfonamide, among others.It also relates to a Pharmaceutical composition comprising organic compounds of formulas (i) and (ii) (IX) and a pharmaceutically acceptable excipient.The Invention is useful for the treatment of depression, cardiovascular diseases, respiratory diseases and diseases pisquiatricas.La presente invencion refiere a compuesto organicos de formulas (I), (Ix) y (II): donde: RAA se selecciona del grupo que consiste en F, Cl, Br, I, -CN, entre otros el anillo A es un heteroarilo de 5-12 miembros o un heterociclilo de 3-15 miembros el anillo B es un carbociclilo de 5,6 o 7 miembros o un heterociclilo de 5,6 o 7 miembros R1a es H o alquilo C1-C4 R1b es H o alquilo C1-C4 R2 se selecciona del grupo que consiste en H, F, Cl, entre otros R3, R4 y R5 se
