BABICH, Olga,LUO, Robert Z.,WANG-FISCHER, Yanlin,PALLING, David J.,VENKATACHALAN, Srinivasan P.
申请号：
ES14767550
公开号：
ES2687481T3
申请日:
2014.03.13
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
compound of Formula (I), ** Formula ** or a pharmaceutically acceptable salt or a stereoisomeric or tautomeric form thereof, wherein: Z is -O- or -S-； Y is - (CH2) 3-NR9R10 R1 is a partially unsaturated or aromatic heterocycle of 5 or 6 elements； R2 is independently at each occurrence -F, -Cl, -Br, -CH3 or -CN； R3 is independently at each occurrence -H, -F, -Cl, -Br, -CF3, -OCF3, -CN, (C1-C12) alkyl or (C1-C12) alkoxy； R9 is (C1-C6) alkyl, (C3-C8) cycloalkyl, pyrazolyl or pyridinyl； wherein R9 is optionally further substituted with 1 or 2 substituents selected from the group consisting of -COOH, -COOR11, -CONR11R12, -SO2R11, -SO2NR11R12, -OH, -CN, -OR11, and -NR11R12； wherein R11 and R12 can form a 6-element heterocycloalkyl ring R10 is R11, -COR11, -COOR11, -SO2R11, 5-methyl-2-oxo-1,3-dioxol-4-yl, ** Formula ** -COO-CH (CH3) OCOCH (CH3) 2； or R9 and R10 together form a piperazinone ring or a heterocycloalkyl ring of 4 to 8 elements, wherein said heterocycloalkyl ring is substituted with 1 or 2 substituents selected from the group consisting of -COOH, -COOR11, -CH2-COOR11, - OH, -NH2, -CN, and (C1-C8) alkoxy； R11 and R12 are independently H or (C1-C6) alkyl, optionally substituted with a heterocycloalkyl ring of 4 to 8 elements； and m and n are each independently 1, 2, 3, or 4.compuesto de Fórmula (I), **Fórmula** o una sal farmacéuticamente aceptable o una forma estereoisómera o tautómera del mismo, en la que: Z es -O- o -S-； Y es -(CH2)3-NR9R10 R1 es un heterociclo parcialmente insaturado o aromático de 5 o 6 elementos； R2 es independientemente en cada ocurrencia -F, -Cl, -Br, -CH3 o -CN； R3 es independientemente en cada ocurrencia -H, -F, -Cl, -Br, -CF3, -OCF3, -CN, alquilo(C1-C12) o alcoxi(C1-C12)； R9 es alquilo(C1-C6), cicloalquilo(C3-C8), pirazolilo o piridinilo； en la que R9 está opcionalmente sustituido adicionalmente con 1 o 2 sustituyentes seleccionados del grupo que consiste en -COOH, -COOR11, -CONR11R12, -SO2R11, -SO2NR11R12, -OH, -CN, -OR11, y -NR11R12；
