DERIVADOS DE 6-OXO-1,6-DIHIDROPIRIDAZIN-4-CARBOXAMIDA N-SUSTITUIDAS CON ANILINO-(BENCIL O PIRIDINILMETIL)-CARBAMOILO COMO ANTAGONISTAS DEL RECEPTOR DE BRADIQUININA 1 (B1)
Refers to a compound of formula I, wherein R1 is 6 - oxo - 5.6 - dihydro - pyridazin-3 4il R2 is H, CH3 R3 and R4 with the C Atom to which they are United to form cicloalquileno C3 C6 R5 is H, CH3, R6 is H, F, CL, Methyl R7 is h, F, CL, BR, CN, CF3, c1-c4 alkyl, CHF2 R9 R8 is H, F, CL, BR, alkyl C 1 - C4, or c1-c4 alkyl -, S - (c1-c4 alkyl) R11 is R10 is H, F, CL, BR, CN, CF3, c1-c4 alkyl,Among others X is CH, N compounds are preferred: (1 - {[5 - (4 - chlorine - 2 - trifluoromethyl - phenylamino) - pyridin - 2 - ylmethyl]} - carbamoyl - cyclopropyl amide acid) - 6 - oxo - 1.6 - dihydro - 4 - carboxylic pyridazin-3 {3 - [2-fluoro-4 - (4 - fluoro - 2 - trifluoromethyl - phenylamino) - bencilcarbamoil] - tetrahydrofuran-3-yl} - D amide The Acid (S) - 2 - oxo - 1.6 - dihydro - 4 - carboxylic pyridazin-3 among others.In addition to such a preparation procedure. These compounds are useful in the treatment of acute pain, neuropathic pain, inflammatory, tumor vicerales, and HeadachesSE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R1 ES 6-OXO-5,6-DIHIDRO-PIRIDAZIN-4IL R2 ES H, CH3 R3 Y R4 JUNTO AL ATOMO DE C AL QUE ESTAN UNIDOS FORMAN CICLOALQUILENO C3-C6 R5 ES H, CH3 R6 ES H, F, Cl, METILO R7 ES H, F, Cl, Br,-CN, ALQUILO C1-C4, CF3, CHF2 R8 ES H, R9 ES F, Cl, Br, ALQUILO C1-C4, O-ALQUILO C1-C4, S-(ALQUILO C1-C4) R10 ES H R11 ES F, Cl, Br, -CN, ALQUILO C1-C4, CF3, ENTRE OTROS X ES CH, N. SON COMPUESTOS PREFERIDOS: (1-{[5-(4-CLORO-2-TRIFLUOROMETIL-FENILAMINO)-PIRIDIN-2-ILMETIL]-CARBAMOIL}-CICLOPROPIL)-AMIDA DEL ACIDO 6-OXO-1,6-DIHIDRO-PIRIDAZIN-4-CARBOXILICO {3-[2-FLUORO-4-(4-FLUORO-2-TRIFLUOROMETIL-FENILAMINO)-BENCILCARBAMOIL]-TETRAHIDROFURAN-3-IL}-AMIDA DEL ACIDO (S)-6-OXO-1,6-DIHIDRO-PIRIDAZIN-4-CARBOXILICO ENTRE OTROS. REFERIDA ADEMAS A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE DOLORES AGUDOS, DOLORES VICERALES, NEUROPATICOS, INFLAMATORIOS, TUMORALES ASI COMO DOLORES DE CABEZA
