SALAS SOLANA, JORGE,SOLIVA SOLIVA, ROBERT,RODRIGUEZ ESCRICH, SERGIO,SICRE GONZALES, MARIA CRISTINA,ALMANSA ROSALES, CARMEN
申请号：
PE0006002012
公开号：
PE13522012A1
申请日:
2010.10.29
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Relates to Heterocyclic compounds of formula (i) or (ii) where a and B are each C o n W is n or CH R1 and R2 are each h, alkyl (c1-c4), hidroxialquilo (c1-c4), CN, among others R3 is alkyl (C1 - C4, R9) - alkyl (c1-c4), among others, where R0 is Halogen, CN, among others R4 is H, alkyl ( C1 - C4), haloalquilo (c1-c4), among others R5 is H, alkyl (c1-c4), (c1-c4) - alkoxy alkyl (c1-c4),Among others, R6 is H, alkyl (c1-c4), hidroxialquilo (c1-c4), among others.Preferred compounds are: (S) - 3 - (2 - (5 - cianopirazol [1,5-a] pyridin-3-yl) - 8 - oxo - 7H - slurry - 9 (8h) - yl) - n, N - 1 - dimetilpiperidin sulfonamide 3 - (9 - (1 - acetilpirrolidin - 3 - yl) - 7 - methyl - 2 - oxo - 8.9 - dihydro 7H - slurry - 2 - il) pyrazolo [1,5-a] pyridin - 5 - carbonitrilo acid (2R) - 2 - [2 - (5 - cianopirazolo [1,5-a] pyridin-3-yl) - 8 - or XO - 7.8 - dihydro - 9h purin - 9 - il] propanoic acid among others.It also relates to a preparation method and a Pharmaceutical composition. These compounds are ihnibidores Janus Kinase (JAK) being useful in the treatment of rheumatoid arthritis, psoriasis, multiple sclerosisSE REFIERE A COMPUESTOS HETEROCICLICOS DE FORMULA (I) O (II) DONDE A Y B SON CADA UNO C O N W ES CH O N R1 Y R2 SON CADA UNO H, ALQUILO(C1-C4), HIDROXIALQUILO(C1-C4), CN, ENTRE OTROS R3 ES ALQUILO(C1-C4), R9-ALQUILO(C1-C4), ENTRE OTROS, EN DONDE R9 ES HALOGENO, CN, ENTRE OTROS R4 ES H, ALQUILO(C1-C4), HALOALQUILO(C1-C4), ENTRE OTROS R5 ES H, ALQUILO(C1-C4), ALCOXI(C1-C4)-ALQUILO(C1-C4), ENTRE OTROS R6 ES H, ALQUILO(C1-C4), HIDROXIALQUILO(C1-C4), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (S)-3-(2-(5-CIANOPIRAZOL[1,5-a]PIRIDIN-3-IL)-8-OXO-7H-PURIN-9(8H)-IL)-N,N-DIMETILPIPERIDIN-1-SULFONAMIDA 3-(9-(1-ACETILPIRROLIDIN-3-IL)-7-METIL-8-OXO-8,9-DIHIDRO-7H-PURIN-2-IL)PIRAZOLO[1,5-a]PIRIDIN-5-CARBONITRILO ACIDO (2R)-2-[2-(5-CIANOPIRAZOLO[1,5-a]PIRIDIN-3-IL)-8-OXO-7,8-DIHIDRO-9H-PURIN-9-IL]PROPANOICO ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSIC
