EASTWOOD, PAUL ROBERT,GONZALES RODRIGUEZ, JACOB,GOMEZ CASTILLO, ELENA,BACH TANA, JORDI
申请号：
PE0022122012
公开号：
PE02342013A1
申请日:
2011.06.14
申请国别(地区):
PE
年份:
2013
代理人:
摘要：
Refers to imidazolona heteroaryl derivative compounds of formula (i) where M and q are each of 0 to 3 Z and V are each N or C W is n or Cr3 W is n or CR2 W is n or CR4 X and y are each n o CR5 and is n or CR5, where R1, R2, R3, R4 and R5 are each h, halogen, alkyl ((C1 - C6) Alquenilo (c2-c4), cycloalkyl (C3 - C10), among others, R6, R7, R9 and R10 are each h,Hidroxialquilo (c1-c4), alkyl (c1-c4) - or - alkyl (c1-c4), among others, R8 and R11 are each h, halogen, alkyl (C1 - C6), alquinilo (c2-c4), aryl (C5 - C14), among others.Preferred compounds are: 3 - oxo - [8 - (9 - tetrahydro - 2H - piran - 4-yl) - 8.9 - dihydro 7H - slurry - 2 - il] imidazo [1,2-a] pyridine - 6 - carbonitrilo 3 - [3 - (2 - metilciclohexil) - 2 - oxo - 2,3 dihydro - 1H imidazo [4,5-b] pyridin - 5 - il] imidazo [1,2-a] pyridine - 3 - 6 - 9 - carbonitrilo {[(4R) - 8 - fluoro - 3,4-dihydro - 2H - cromen - 4-yl] - 8 - oxo - 8.9 - dihydro 7H - slurry - il - 2} imidazo [1,2-a] pyridine - 6 - carbonitrilo among others.It also relates to a Pharmaceutical composition. These compounds are inhibitors of JAK3 JAK1, JAK2 and being useful in the treatment of polycythemia vera myelofibrosis, rheumatoid arthritis, multiple sclerosisSE REFIERE A COMPUESTOS DERIVADOS DE HETEROARIL IMIDAZOLONA DE FORMULA (I) DONDE m Y p SON CADA UNO DE 0 A 3 Z Y V SON CADA UNO N O C W ES N O CR3 W ES N O CR2 W ES N O CR4 X E Y SON CADA UNO N O CR5 Y ES N O CR5, EN DONDE R1, R2, R3, R4 Y R5 SON CADA UNO H, HALOGENO, CN, ALQUILO(C1-C6), ALQUENILO(C2-C4), CICLOALQUILO(C3-C10), ENTRE OTROS R6, R7, R9 Y R10 SON CADA UNO H, HIDROXIALQUILO(C1-C4), ALQUIL(C1-C4)-O-ALQUILO(C1-C4), ENTRE OTROS R8 Y R11 SON CADA UNO H, HALOGENO, ALQUILO(C1-C6), ALQUINILO(C2-C4), ARILO(C5-C14), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 3-[8-OXO-9-(TETRAHIDRO-2H-PIRAN-4-IL)-8,9-DIHIDRO-7H-PURIN-2-IL]IMIDAZO[1,2-a]PIRIDINA-6-CARBONITRILO 3-[3-(2-METILCICLOHEXIL)-2-OXO-2,3-DIHIDRO-1H-IMIDAZO[4,5-b]PIRIDIN-5-IL]IMIDAZO[1,2-a]PIRIDINA-6-CARBONITRILO 3-{9-[(4R)-8-
