Choi Wonshik,Dasari Ramachandra,Fang-Yen Christopher,Feld Michael
申请号:
US201414490242
公开号:
US9546952(B2)
申请日:
2014.09.18
申请国别(地区):
美国
年份:
2017
代理人:
McCarter & English, LLP
摘要:
The present invention relates to systems and methods for quantitative three-dimensional mapping of refractive index in living or non-living cells, tissues, or organisms using a phase-shifting laser interferometric microscope with variable illumination angle. A preferred embodiment provides tomographic imaging of cells and multicellular organisms, and time-dependent changes in cell structure and the quantitative characterization of specimen-induced aberrations in high-resolution microscopy with multiple applications in tissue light scattering.