Slaski Uniwersytet Medyczny w Katowicach;Instytut Biopolimerów I Wlókien Chemicznych
发明人:
申请号：
EP17210150.3
公开号：
EP3338817A1
申请日:
2017.12.22
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The object of the invention is a prosthesis for regeneration of nerves consisting of a core with a length of 5-50 mm placed in a sleeve in the shape of a cylinder with a wall thickness of 0.04-1.0 mm and an internal diameter of 1-10 mm. The sleeve is made from DL-lactide/glycolide copolymer with a molar ratio of 75/25, and the core is made from chitosan with a mean molecular weight of 100-500 kDa and a deacetylation degree of 80-98%, wherein the chitosan is in the form of filled fibres with a diameter of 20-40 µm. The chitosan fibres which constitute the core are placed in the sleeve in parallel to the axis of the said sleeve and they are present in the state of stress. The quantity of chitosan fibres is from 150-22500. In addition, the core is placed in the sleeve so that the sleeve protrudes beyond both core ends.The object of the invention is also a method of manufacturing the above mentioned prosthesis for regeneration of nerves.
