METHODE DE TRAITEMENT DE MALADIES AUTO-IMMUNES A L'AIDE DE CELLULES T CD4 MODIFIEES EN VUE D'OBTENIR UNE STABILISATION DE L'EXPRESSION DU GENE FOXP3 ENDOGENE
SEATTLE CHILDREN'S HOSPITAL (DBA SEATTLE CHILDREN'S RESEARCH INSTITUTE
发明人:
SCHARENBERG, ANDREW M.,RAWLINGS, DAVID J.,TORGERSON, TROY
申请号：
CA3042179
公开号：
CA3042179A1
申请日:
2016.10.31
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Disclosed are methods of making a genetically cell that expressed FOXP3 and methods of treatment. In some embodiments, the method can providing a first nucleotide sequence, wherein the first nucleotide sequence comprises a coding strand, the coding strand comprising one or more regulatory elements and a FOXP3 gene or portion thereof providing a nuclease and performing a gene editing process on the first nucleotide sequence, which edits said one or more regulatory elements, and optionally edits the FOXP3 gene or portion thereof. Methods of treating a subject suffering from an autoimmune disease and subjects suffering the effects of organ transplantation are also provided.
