Aspects of the invention are directed to arginine-free polypeptide-containing compositions and methods for treating disorders associated with inflammation or the autoimmune response. In particular, the polypeptide is etanercept.Des aspects de l'invention concernent des compositions contenant un polypeptide exempt d'arginine et des méthodes de traitement de troubles associés à une inflammation ou à la réponse auto-immune. En particulier, le polypeptide est l'étanercept.