FORMULATIONS LIQUIDES PHARMACEUTIQUES STABLES DE LA PROTÉINE DE FUSION TNFR:FC

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专利权人:

Sandoz AG

发明人:

申请号：

EP12715107.4

公开号：

EP2699265B1

申请日:

2012.04.19

申请国别(地区):

EP

年份:

2019

代理人:

摘要：

The present invention relates to stable pharmaceutical liquid formulations of the fusion protein TNFR:Fc comprising different buffer systems and stabilizers. In particular, it could be demonstrated that the physical stability of TNFR:Fc is significantly improved by using a citrate buffer system and lysine as stabilizer.

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