Yoshimasa Sasabuchi;Minoru Yamamoto;Takahiro Honda;Kenji Kawashima;Kazuyoshi Okamoto;Hisashi Tajima;Masakazu Ban
发明人:
Takahiro Honda,Hisashi Tajima,Yoshimasa Sasabuchi,Kenji Kawashima,Kazuyoshi Okamoto,Minoru Yamamoto,Masakazu Ban
申请号：
US13449921
公开号：
US08518973B2
申请日:
2012.04.18
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A compound having the following formula [I] or a pharmaceutically acceptable salt thereof:wherein A is an aromatic five-membered heterocycle which optionally is fused with a cycloalkane ring； B is an alkylene； R1 and R2 are hydrogen, hydroxyl, alkoxy, aryloxy, alkyl, cycloalkyl, aryl, heterocycle, amino, alkylamino, arylamino or acyl, or R1 and R2 join together to form a heterocycle； X and Y are hydrogen, halogen, hydroxyl, alkoxy, aryloxy, alkyl, cycloalkyl, aryl, mercapto, alkylthio, arylthio, carboxyl, an ester of carboxyl, an amide of carboxyl, cyano or nitro； p is 0, 1 or 2； and q is 0 or 1. The compound is useful for treating diseases in which angiogenesis or augmentation of vascular permeability is involved.
