GRAUPE, MICHAEL,LINK, JOHN O.,VENKATARAMANI, CHANDRASEKAR
申请号：
ES06774467
公开号：
ES2552712T3
申请日:
2006.06.29
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of Formula (I): ** Formula ** wherein E is -COCONHR6 where R6 is hydrogen, alkyl, cycloalkyl, aralkyl, or heteroaralkyl, wherein the aromatic ring is optionally substituted with one or two halo groups； R1 is alkyl, haloalkyl, alkenyl, alkynyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclyl or heterocyclylalkyl wherein the aliphatic, alicyclic and aromatic groups in R1 are optionally substituted with one or two Rb independently selected from hydroxy, alkoxy, , heteroaryloxy, alkylthio, arylthio, heteroarylthio, amino, monosubstituted amino, disubstituted amino, alkylsulfonyl, arylsulfonyl, carboxy, alkoxycarbonyl, acylamino, aminocarbonyl, halo, or cyano and further where the aromatic or alicyclic ring in Rb is optionally substituted with one, two, or three substituents independently selected from alkyl, alkoxy, halo, haloalkyl, haloalkoxy, cyano, carboxy, or carboxyalkyl； X is -O-, -NR14- -S-, -SO-, or -SO2-； R3 is alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclyl or heterocyclylalkyl where the aliphatic, alicyclic and aromatic groups in R3 are optionally substituted with one or two independently selected hydroxy Rc , haloalkoxy, aryloxy, heteroaryloxy, alkylthio, arylthio, heteroarylthio, amino, monosubstituted amino, disubstituted amino, alkylsulfonyl, arylsulfonyl, carboxy, alkoxycarbonyl, acylamino, aminocarbonyl, halo, or cyano and further where the aromatic or alicyclic ring is in Rc substituted with one, two, or three substituents independently selected from alkyl, alkoxy, halo, haloalkyl, haloalkoxy, carboxy, or carboxy alkyl； Y is -NHC (O) NH-； R2 is a group of formula (a): ** Formula ** where: Rd1 is hydrogen, hydroxy, alkoxy, amino, alkylamino or dialkylamino； Rd and Rd2 are independently hydrogen, alkyl, halo, alkoxy, alkylthio, alkylsulfonyl or； and Rd3 is a ** Formula ** group of formula: optionally substituted with halo, alkyl, cycloalkyl, cycloal
