(54) ZASTOSOWANIE (3-TRIFLUOROMETYLOSULFONYLO)-N-[4-METYLO-3-(4-PIRYDYN-3-YLOPIRYMIDYN-2-YLOAMINO)FENYLO]BENZAMIDU PRZECIW RAKOWI PIERSI, GLEJAKOWI i ANGIOGENEZIE

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专利权人:

Natco Pharma Limited

发明人:

KOMPELLA, AMALA KISHAN,ADIBHATLA KALI SATYA, BHUJANGA RAO,RACHAKONDA, SREENIVAS,VENKAIAH CHOWDARY, NANNAPANENI

申请号：

PL09717380

公开号：

PL2254882T3

申请日:

2009.03.02

申请国别(地区):

PL

年份:

2013

代理人:

摘要：

A method of preparing (3-trifluoromethylsulfonyl)-N-[4-methyl-3-nitrophenyl]-benzamide, the method comprising: providing a compound of formula VI, (3-trifluomethylsulfonyl) benzoyl chloride； condensing 4-methyl-3-nitro-aniline with the compound of formula (VI) at 30 to 40°C in chlorohydrocarbon solvent with aqueous alkali addition to obtain a compound of formula (III) (3-trifluoromethylsulfonyl)-N-[4-methyl-3-nitrophenyl]-benzamide.

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