ELEMENTS REGULATEURS D'ACIDES NUCLEIQUES SPECIFIQUES AU DIAPHRAGME ET METHODES ET UTILISATION ASSOCIEES

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专利权人:

VRIJE UNIVERSITEIT BRUSSEL

发明人:

CHUAH, LAY KHIM,VANDENDRIESSCHE, THIERRY,TULALAMBA, WARUT

申请号：

CA3057899

公开号：

CA3057899A1

申请日:

2018.03.27

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

The present invention relates to nucleic acid regulatory elements that are able to enhance diaphragm-specific expression of genes, in particular expression in diaphragm as such, or in combination with expression in cardiac muscle and/or skeletal muscle, methods employing these regulatory elements and uses of these elements. Expression cassettes and vectors containing these nucleic acid regulatory elements are also disclosed. The present invention is particularly useful for applications using gene therapy, more particularly diaphragm-directed gene therapy, and for vaccination purposes.

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