Diaphragm-specific nucleic acid regulatory elements and methods and use thereof

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专利权人:

Vrije Universiteit Brussel

发明人:

Chuah, Lay Khim,Vandendriessche, Thierry,Tulalamba, Warut

申请号：

AU2018241847

公开号：

AU2018241847A1

申请日:

2018.03.27

申请国别(地区):

AU

年份:

2019

代理人:

摘要：

The present invention relates to nucleic acid regulatory elements that are able to enhance diaphragm-specific expression of genes, in particular expression in diaphragm as such, or in combination with expression in cardiac muscle and/or skeletal muscle, methods employing these regulatory elements and uses of these elements. Expression cassettes and vectors containing these nucleic acid regulatory elements are also disclosed. The present invention is particularly useful for applications using gene therapy, more particularly diaphragm-directed gene therapy, and for vaccination purposes.

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