PROBLEM TO BE SOLVED: To provide compositions for the prevention or improvement of metabolic disorders comprising an SIRT-1 (Sirtuin-1) activator for activating SIRT-1.SOLUTION: The present invention relates to compositions including compounds represented by the following formula, derivatives thereof or pharmaceutically acceptable salts thereof. The compound is syringaresinol.SELECTED DRAWING: None【課題】SIRT-1(Sirtuin-1)を活性化させるSIRT-1活性化剤を含む、代謝異常症の予防又は改善用組成物の提供。【解決手段】下記で表される化合物、その誘導体または薬学的に許容し得るその塩を含む、組成物。前記化合物がシリンガレシノールである、組成物。【選択図】なし