PROBLEM TO BE SOLVED: To provide an SIRT-1 activator for activating SIRT-1 for the prevention or improvement of eye diseases.SOLUTION: The present invention relates to an SIRT-1 activator including, as an active ingredient, a lignan compound such as syringaresinol represented by the following formula, derivatives thereof or pharmaceutically acceptable salts thereof.SELECTED DRAWING: None【課題】眼疾患の予防又は改善するためのSIRT-1を活性化させるSIRT-1活性化剤の提供。【解決手段】下記式で表される、シリンガレシノール等のリグナン系化合物、その誘導体又は薬学的に許容し得るその塩を有効成分として含むSIRT-1活性化剤。【選択図】なし