The present invention relates to a SIRT-1 activator comprising a compound represented by general formula 1, a derivative thereof or a pharmaceutically acceptable salt thereof as an active ingredient. The present invention also relates to a composition for detoxification, for improving metabolic disorders, for preventing or improving eye diseases, or for preventing or improving immune diseases, comprising the SIRT-1 activator.本発明は、一般式1で示される化合物、その誘導体または薬学的に許容し得るその塩を有効成分として含むSIRT-1活性化剤に関する。また、本発明は、前記SIRT-1活性化剤を含む解毒用、代謝異常症の改善用、眼疾患の予防又は改善用、または免疫性疾患の予防又は改善用組成物に関する。