Fellows; Foundation Scholars; of the College of the Hol;The Provost; and the other members of Board
发明人:
Matthew CAMPBELL,Peter HUMPHRIES,Marian HUMPHRIES,Anna-Sophia KIANG,Sarah DOYLE,Luke O'NEILL
申请号：
US16401787
公开号：
US20190314454A1
申请日:
2019.05.02
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention is directed to compositions and methods for the treatment of degenerative retinal conditions. According to a general aspect, the present invention is directed to inflammatory mediators, preferably components or substrates of the NLRP3-inflammasome, for use in the treatment of degenerative retinal conditions involving drusen and anaphylatoxin-induced choroidal-neovascularisation. The invention is also directed to a method for the treatment of degenerative retinal conditions involving drusen and anaphylatoxin-induced choroidal-neovascularisation and to recombinant vectors and recombinant proteins for use in such methods. The present invention also provides a method for determining the risk of developing or monitoring the progression of diseases involving drusen and anaphylatoxin-induced choroidal neo-vascularisation.
