Fellows; Foundation Scholars;The Provost; of the College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin; and the other members of Board
发明人:
Campbell, Matthew,Humphries, Peter,Humphries, Marian,Kiang, Anna-Sophia,Doyle, Sarah,O'Neill, Luke,ONeill, Luke
申请号：
AU2012314330
公开号：
AU2012314330B2
申请日:
2012.10.01
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
The present invention is directed to compositions and methods for the treatment of degenerative retinal conditions. According to a general aspect, the present invention is directed to inflammatory mediators, preferably components or substrates of the NLRP3-inflammasome, for use in the treatment of degenerative retinal conditions involving drusen and anaphylatoxin-induced choroidal- neovascularisation. The invention is also directed to a method for the treatment of degenerative retinal conditions involving drusen and anaphylatoxin-induced choroidal-neovascularisation and to recombinant vectors and recombinant proteins for use in such methods. The present invention also provides a method for determining the risk of developing or monitoring the progression of diseases involving drusen and anaphylatoxin-induced choroidal neo-vascularisation.
