Provided are a polyurethane resin composition for a hollow fiber membrane potting agent, and a hollow fiber membrane module, and more particularly, a polyurethane resin composition for a hollow fiber membrane potting agent, which includes a polyurethane resin and a hydrophilic additive to have excellent resistance to internal/external pressure, and also to have excellent sealing performance, antifouling property, etc., and a hollow fiber membrane module including a cured product thereof.