The present inventors discovered that the above-mentioned problems can be solved by producing antigen-binding molecules that contain an antigen-binding domain whose antigen-binding activity varies depending on the concentration of a target tissue-specific compound. Use of antigen-binding molecules of the present invention enables various diseases that originate from a target tissue to be treated in a manner specific to the target tissue.本案發明人等發現藉由創作包含依存於標的組織專一性的化合物濃度而改變對抗原的結合活性的抗原結合分域的抗原結合分子，能解決上述課題。藉由使用本發明之抗原結合分子，能標的組織專一性地治療起因於標的組織之各種疾病。
