活化T細胞之雙特異性抗原結合分子农业专利-农业学术服务平台

发明人:: BACAC, MARINA,巴凯克　玛丽娜,巴凱克　瑪麗娜,BRUENKER, PETER,布朗克　彼得,FREIMOSER-GRUNDSCHOBER, ANNE,富雷摩舍　葛伦雪伯　安,富雷摩捨　葛倫雪伯　安,HOSSE, RALF,贺司　雷夫,賀司　雷夫,KLEIN, CHRISTIAN,克莱　克里斯汀,克萊　克里斯汀,MOESSNER, EKKEHARD,摩斯纳　艾克哈得,摩斯,巴凯克玛丽娜,巴凱克瑪麗娜,布朗克彼得,富雷摩舍葛伦雪伯安,富雷摩捨葛倫雪伯安,贺司雷夫,賀司雷夫,克莱克里斯汀,克萊克里斯汀,摩斯纳艾克哈得

摘要：: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.本發明大體上關於用於T細胞活化及再定向於特定目標細胞的新穎雙特異性抗原結合分子。另外，本發明係關於編碼此雙特異性抗原結合分子的聚核苷酸，以及包含此聚核苷酸的載體及宿主細胞。本發明進一步關於用於製造本發明之雙特異性抗原結合分子的方法，及使用此等雙特異性抗原結合分子於治療疾病的方法。