雙特異性活化T細胞之抗原結合分子农业专利-农业学术服务平台

发明人:: AST, OLIVER,亚斯特　奥立维,亞斯特　奧立維,BRUENKER, PETER,布伦克　彼得,布倫克　彼得,FAUTI, TANJA,佛堤　谭嘉,佛堤　譚嘉,FREIMOSER-GRUNDSCHOBER, ANNE,费摩瑟　葛舒博　安,費摩瑟　葛舒博　安,JAEGER, CHRISTIANE,贾各　克利斯提安,賈各　克利斯提安,KLEIN, CHRISTIAN,克莱　克里斯汀,克萊　克里斯,亚斯特奥立维,亞斯特奧立維,布伦克彼得,布倫克彼得,佛堤谭嘉,佛堤譚嘉,费摩瑟葛舒博安,費摩瑟葛舒博安,贾各克利斯提安,賈各克利斯提安,克莱克里斯汀,克萊克里斯

摘要：: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.本發明大體上係關於用於T細胞活化及重引導至特定目標細胞之新穎雙特異性抗原結合分子。此外，本發明係關於編碼該等雙特異性抗原結合分子之聚核苷酸，及包含該等聚核苷酸之載體及宿主細胞。本發明此外係關於製造本發明之雙特異性抗原結合分子之方法，及使用此等雙特異性抗原結合分子治療疾病之方法。