The present invention relates to a process for the preparation of powder compositions comprising a lipophilic extract of Echinacea spp., a lipophilic extract of Zingiber officinale and phospholipids. The invention also relates to powder compositions obtainable by the process of the invention and pharmaceutical, nutraceutical and cosmetic formulations comprising said compositions. The invention regards the use of the powder compositions and formulations thereof in the prevention and/or treatment of inflammatory and painful states.