CASILLAS LINDA N.,HAILE PAMELA A.,MARQUIS ROBERT W. JR.,WANG GREN
申请号：
NZ62845213
公开号：
NZ628452A
申请日:
2013.09.13
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed are prodrugs of 2-((4-(benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethanol having Formula (I). The compounds are useful in the inhibition of RIP2 kinase and can be used to treat diseases such as uveitis, interleukin-1 converting enzyme associated fever syndrome, dermatitis, acute lung injury, type 2 diabetes mellitus, arthritis, rheumatoid arthritis, ulcerative colitis, Crohn&rsquo；s disease, early-onset inflammatory bowel disease, extraintestinal inflammatory bowel disease, prevention of ischemia reperfusion injury in solid organ transplant, non-alcohol steatohepatitis, alcohol steatohepatitis, autoimmune hepatitis, asthma, graft versus host disease, systemic lupus erythematosus, multiple sclerosis, sarcoidosis, Blau syndrome/early-onset sarcoidosis, Wegner&rsquo；s granulomatosis, and interstitial pulmonary disease. Also discloses is the method of making the compounds.
