ROGER KINGDON CRAIG,FRANKLIN GERARDUS GROSVELD,RICHARD WILHELM JANSSENS,MARINUS JOHANNES VAN HAPEREN
申请号：
IN5532/DELNP/2011
公开号：
IN2011DN05532A
申请日:
2011.07.18
申请国别(地区):
IN
年份:
2013
代理人:
摘要：
A non-human mammal containing an endogenous lambda light chain gene locus, an endogenous kappa light chain gene locus and an endogenous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and light chain genes are formed and expressed in B-cells following antigen challenge but said loci have been mutated so that the ability to form functional immunoglobulin tetramers comprising re-arranged heavy and light chains produced from said mutated loci has been substantially reduced or eliminated.
