Roger Craig;Erasmus University Medical Center Rotterdam
发明人:
Craig, Roger Kingdon,Grosveld, Franklin Gerardus,Janssens, Richard Wilhelm,Van Haperen, Mapinus Johannes
申请号：
AU2009329365
公开号：
AU2009329365B2
申请日:
2009.11.30
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
A non-human mammal containing an endogenous lambda light chain gene locus, an endogenous kappa light chain gene locus and an endogenous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and light chain genes are formed and expressed in B-cells following antigen challenge but said loci have been mutated so that the ability to form functional immunoglobulin tetramers comprising re-arranged heavy and light chains produced from said mutated loci has been substantially reduced or eliminated.
