A compound of formula (Ib) or (Ic) ** Formula ** or an enantiomer, a diastereomer, a tautomer or a salt thereof, in which: X is H, F, Cl, Br, I, C1- alkoxy 10, C1-10 haloalkyl, 4-12 membered heterocyclyl, -CO2R11 or -NR11R12； Y is H, F, Cl, Br, I, C1-10 alkoxy, C1-10 haloalkyl, 4-12 membered heterocyclyl, -CO2R11 or -NR11R12； Z is H, Cl, Br, I, C1-10 alkoxy, C1-10 haloalkyl, 4-12 membered heterocyclyl or -NR11R12； R11 and R12, at each occurrence, are independently selected from H, C1-10 alkyl, C1-10 haloalkyl, C3-10 cycloalkyl, C6-10 aryl, a 4-12 membered heteroaryl and a 4-12 membered heterocyclyl, wherein the alkyl, cycloalkyl, aryl, heteroaryl and heterocyclyl can be optionally substituted with one or more R13 and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3 or 4 heteroatoms independently selected from the group that consists of N, S or O； R13a is independently H, -OH, F, Cl, Br, I, C1-10 alkyl, C2-10 alkoxy, C1-10 haloalkyl, C3-10 cycloalkyl, C2-12 alkenyl, C6-10 aryl, a heteroaryl of 4 with 12 members, a 4 to 12 membered heterocyclyl, a 4 to 12 membered heteroaryl-C1-10 alkyl, -CN, - (CH2) m-SO2R14, -NR14SO2R14, -CONR14R14, - (CH2) m-NR14SO2R14, - (CH2) n-NR14SO2NR14R14, -NR14SO2NR14R14, -CO2NR14R14, -NR14CO2NR14R14, -NR14COR14, -SO2NR14COR14, - SO2NR14CONR14R14, -NR14CO2R14, -CO2R14 or -NR14R14, wherein alkyl, cycloalkyl, alkenyl, alkoxy, the aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R14a and heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3 or 4 heteroatoms independently selected from the group consisting of N, S or O； R13a-2 is independently H, -OH, F, Br, I, C1-10 alkyl, C1-10 alkoxy, C1-10 haloalkyl, C3-10 cycloalkyl, C2-12 alkenyl, C6-10 aryl, a heteroaryl of 4 to 12 members, a 4 to 12 membered heterocyclyl, a 4 to 12 membered heteroaryl-C1-10 alkyl, - (CH2) m-SO2R14, -NR14SO2R14, -CONR14R14, - (CH2) m-SO2NR14R14, - (CH2 ) m- NR14SO2R14, - (CH3) n-NR14SO2NR14R14, -NR14SO2NR14R14,
