Hideo Saji,Nobuya Inagaki,Hiroyuki Kimura,Kentaro Toyoda,Hirokazu Matsuda,Mikako Ioroi,Asami Kon
申请号：
US14648467
公开号：
US09950083B2
申请日:
2013.11.29
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A peptide that can be used as an imaging probe for GLP-1R is provided. In an embodiment, a polypeptide is represented by the following formula (3)；(Sequence ID No. 3)Xaa1-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser (3)where Xaa1 represents an aspartic acid in which a —Y—X′ group binds to an α-amino group, X′ includes a chelating site and a radioactive metal nuclide chelated by the chelating site, the chelating site being diethylenetriaminepentaacetic dianhydride (DTPA) or 1,4,7-triazacyclononnane-N,N′,N″-triacetic acid (NOTA), and Y represents a linker including a group selected from the group consisting of —CH2—(C6H4)—, —NH—C(═S)—, —NH—(CH2)5—C(═O)—, and a combination thereof.
