用於反義遞送之細胞穿透肽农业专利-农业专业知识服务系统

发明人:: WOLFE, JUSTIN M.,沃夫　贾斯汀　Ｍ,沃夫　賈斯汀　Ｍ,FADZEN, COLIN M.,菲德森　科林　Ｍ,CHOO, ZI-NING,朱　志宁,朱　志寧,HOLDEN, REBECCA L.,霍登　蕾贝卡　Ｌ,霍登　蕾貝卡　Ｌ,YAO, MONICA,姚　莫妮卡,HANSON, GUNNAR J.,韩森　甘纳　Ｊ,韓森　甘納　Ｊ,PENTELUTE,

摘要：: Provided herein are oligonucleotides, cell penetrating peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject oligonucleotides, peptides, and peptide-oligonucleotide-conjugates described herein.本發明提供寡核苷酸、細胞穿透肽及肽-寡核苷酸結合物。本發明亦提供治療有需要之受試者之肌肉疾病、病毒感染或細菌感染之方法，該方法包含向該受試者投與本文中所描述之寡核苷酸、肽及肽-寡核苷酸結合物。