It is disclosed a pharmaceutical composition containing an oligonuclelotide chelate complex and at least one polypeptide or pegylated polypeptide. The present disclosure also describes additional pharmaceutical compositions and methods for the treatment of diseases including viral infections.本發明揭示一種醫藥組合物,其含有寡核苷酸螯合複合物及至少一種多肽或聚乙二醇化多肽。本發明亦描述用於治療疾病(包括病毒感染)之其他醫藥組合物及方法。