雙環肽寡核苷酸結合物农业专利-农业专业知识服务系统

发明人:: WOLFE, JUSTIN M.,沃夫　贾斯汀　Ｍ,沃夫　賈斯汀　Ｍ,FADZEN, COLIN M.,菲德森　科林　Ｍ,菲德森　科林　Ｍ,HOLDEN, REBECCA L.,霍登　蕾贝卡　Ｌ,霍登　蕾貝卡　Ｌ,YAO, MONICA,姚　莫妮卡,姚　莫妮卡,HANSON, GUNNAR J.,韩森　甘纳　Ｊ,韓森　甘納　Ｊ,PENTELUTE, BRADLEY L.,潘特卢特　布莱德利　Ｌ,潘

摘要：: Provided herein are oligonucleotides, bicyclic peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject oligonucleotides, peptides, and peptide-oligonucleotide-conjugates described herein.本發明提供寡核苷酸、雙環肽及肽-寡核苷酸結合物。本發明亦提供治療有需要之受試者之肌肉疾病、病毒感染或細菌感染之方法，其包含向該受試者投與本文中所描述之寡核苷酸、肽及肽-寡核苷酸結合物。