Provided herein are peptide-oligomer-conjugates. Also provided herein are methods of treating a central nervous system disorder, a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject peptide-oligomer-conjugates described herein.本發明提供肽寡聚物結合物。本發明亦提供治療有需要個體之中樞神經系統病症、肌肉疾病、病毒性感染或細菌性感染的方法,其包含向該個體投與本s4 所描述之肽寡聚物結合物。