compound of formula i and ii, pharmaceutical composition, method of inhibiting abnormal cell growth or treating a hyperproliferative disorder in a mammal and method of treating an inflammatory disease in a mammal
JOSEPH LYSSIKATOS,PASCAL PIERRE SAVY,PHILIP JACKSON,ROBERT ANDREW HEALD,STEPHEN PRICE
申请号：
BRPI0910175
公开号：
BRPI0910175A2
申请日:
2009.07.01
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
The invention relates to bicyclic heterocycles of formulae I and II with anti-cancer and/or anti-inflammatory activity and more specifically with MEK kinase inhibitory activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth, treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
