"compound, pharmaceutical composition, method of treating a hyperproliferative disorder in a mammal, process for preparing a pharmaceutical composition, method for inhibiting or modulating lipid kinase activity in a mammal, kit for treating condition mediated by pi3k and method of preparing a compound of the formula
ADRIAN FOLKES,DANIEL P. SUTHERLIN,GEORGETTE CASTANEDO,IRINA CHUCKOWREE,NAN CHI WAN
申请号：
BRPI0909614
公开号：
BRPI0909614A2
申请日:
2009.05.29
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
Purine compounds of Formula I, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
