Yang William C.,Huang Yao-Ming,McElearney Kyle,Tescione Lia,Lambropoulos James,Zhang An,Tsang Valerie Liu,Ryll Thomas,Lee Sangil,Lee Dae Sung
申请号：
US201815953746
公开号：
US2019085369(A1)
申请日:
2018.04.16
申请国别(地区):
美国
年份:
2019
代理人:
摘要：
The present invention pertains to a cell culture medium comprising media supplements that are shown to control recombinant protein glycosylation and/or cell culture in a controlled or modulated (shifted) temperature to control recombinant protein glycosylation and/or cell culture with controlled or modulated seed density to control recombinant protein glycosylation, and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.
