Disclosed is an isolated human antibody molecule, which a) binds to human IGF-l and IGF-2 such that i) binding of IGF-l and IGF-2 to the IGF-l receptor is prevented and ii) IGF-l receptor-mediated signaling is inhibited, b) binds to mouse and rat IGF-l and IGF-2, does not bind to human insulin； wherein said antibody molecule is c) an antibody molecule that has heavy chain CDRs comprising the amino acid sequences of SEQ ID NO:2l (CDR1), SEQ ID NO:22 (CDR2) and SEQ ID NO:23 (CDR3) and that has light chain CDRs comprising the amino acid sequences of SEQ ID NO:24 (CDR1), SEQ ID NO:25 (CDR2) and SEQ ID NO:26 (CDR3).
