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נוגדנים בי–ספציפיים המעכבים pdgfr beta ו–a–vegf , תכשירים, שימושיהם ושיטות לייצורם
专利权人:
ZYMOGENETICS INC.
发明人:
申请号:
IL20761810
公开号:
IL207618A
申请日:
2010.08.15
申请国别(地区):
IL
年份:
2014
代理人:
摘要:
There is provided an isolated antibody that binds to the extracellular domain of PDGFR² and neutralizes PDGFR² activity, said antibody comprising a V L domain comprising CDRs LCDR1, LCDR2, and LCDR3 and a V H domain comprising CDRs HCDR1, HCDR2, and HCDR3, wherein: LCDR1 has the amino acid sequence shown in SEQ ID NO: 433, optionally the amino acid sequence shown in SEQ ID NO: 443; LCDR2 has the amino acid sequence shown in SEQ ID NO: 434; LCDR3 has the amino acid sequence shown in SEQ ID NO: 435, optionally the amino acid sequence shown in SEQ ID NO: 444; HCDR1 has the amino acid sequence shown in SEQ ID NO: 436, optionally the amino acid sequence shown in SEQ ID NO: 445; HCDR2 has the amino acid sequence shown in SEQ ID NO: 437; HCDR3 has an amino acid sequence selected from the group consisting of SEQ ID NOs: 438-442
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来源网址:
http://www.ckcest.cn/home/
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