SYROV, Kirill Konstantinovich,NESTERUK, Vladimir Viktorovich
申请号：
EP17820624
公开号：
EP3479822A4
申请日:
2017.06.28
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The invention relates to the chemical-pharmaceutical industry, and specifically to a pharmaceutical composition in a tablet form comprising: 2.0 to 15.0 wt% of memantine； 1.5 to 10.0 wt% of melatonin； 65.0 to 80.0 wt% of a filler selected from mannitol or a mannitol and copovidone mixture； 4.0 to 15.0 wt% of a disintegrant selected from crospovidone； 1.0 to 2.0 wt% of a binder selected from sorbitol； 1.0 to 2.5 wt% of a sweetener selected from maltitol, sodium saccharinate or a mixture thereof； 0.5 to 1.0 wt% of a glidant selected from colloidal silicon dioxide, stearic acid, magnesium stéarate, talc or mixtures thereof； and 1.5 to 3.0 wt% of a flavoring agent； and to a method for preparing the pharmaceutical composition. The invention provides for broadening the range of pharmaceutical compositions comprising a combination of memantine and melatonin, and for increasing the storage stability and dissolution rate thereof.
