Cecile M. Krejsa;Eugene C. Yi;Stephen R. Jaspers;Stacey R. Dillon;Mark W. Rixon;Frederick J. Ramsdell
发明人:
Stephen R. Jaspers,Mark W. Rixon,Stacey R. Dillon,Frederick J. Ramsdell,Cecile M. Krejsa,Eugene C. Yi
申请号：
US12971495
公开号：
US08241629B2
申请日:
2010.12.17
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Human anti-human IL-21 monoclonal antibodies and the hybridomas that produce them are presented. Certain of these antibodies have the ability to bind native human IL-21, a mutant recombinat IL-21 protein and/or peptide regions of human IL-21. These human anti-IL-21 antibodies are useful in therapeutic treatment of autoimmune and inflammatory diseases, particularly diseases mediated by T follicular helper cells, B cells TH cells or TH17 cells.
