Cecile M. KREJSA;Eugene C. YI;Stephen R. JASPERS;Stacey R. DILLON;Mark W. RIXON;Frederick J. RAMSDELL
发明人:
Stephen R. JASPERS,Mark W. RIXON,Stacey R. DILLON,Frederick J. RAMSDELL,Cecile M. KREJSA,Eugene C. YI
申请号：
US13474001
公开号：
US20120225065A1
申请日:
2012.05.17
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Human anti-human IL-21 monoclonal antibodies and the hybridomas that produce them are presented. Certain of these antibodies have the ability to bind native human IL-21, a mutant recombinant IL-21 protein and/or peptide regions of human IL-21. These human anti-IL-21 antibodies are useful in therapeutic treatment of autoimmune and inflammatory diseases, particularly diseases mediated by T follicular helper cells, B cells TH cells or TH17 cells.
