Songping D. Huang,Soumitra Basu,Anatoly K. Khitrin,Mohammadreza Shokouhimehr,Eric Scott Soehnlen
申请号：
US12710633
公开号：
US08580230B2
申请日:
2010.02.23
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A material useful as a MRI contrast agent used for medical imaging, drug delivery platform or other functions are provided as a class of non-gadolinium and non-iron oxide based materials that comprise Prussian blue materials or analogue materials. The materials may be used as T1-weighted and/or T2-weighted MRI contrast agents for imaging, including cellular imaging, in clinical diagnosis and biomedical research applications. The agent is a compound created from Prussian blue materials that is non-toxic, and can be internalized by cells through endocytosis. The Prussian blue materials may also be used for drug delivery applications. The Prussian blue materials may be administered orally to a subject in either medical imaging or drug delivery applications or dual modality MRI-Fluorescence imaging agent.
