China Gateway Pharmaceuticals Development Co.; Ltd
发明人:
申请号:
EP13866998.1
公开号:
EP2940026A1
申请日:
2013.12.30
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
Disclosed are a composition of glucose derivative and proline, a crystal, a preparation method and an application. In an X-ray powder diffraction diagram of the eutectic crystal when the diffraction angle is 2θ, characteristic diffraction peaks comprise 4.339, 11.499, 12.835, 13.921, 15.294, 16.212, 16.804, 17.154, 18.335, 19.274, 19.982, 22.710, 23.218, 24.885, 27.940, 29.612 and 30.313, and the 2θ error range is ±0.1. The method comprises: mixing a compound A solution with an L-proline solution, and performing cooling and crystallization. The present invention furhter provides an application of the crystal in medicine preparation. The eutectic crystal in the present invention features high water-solubility, low hygroscopicity and high stability, and is suitable for manufacturing a variety of preparations.