INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC;Rega Stichting Vzw.
发明人:
HOLY, Antonin,BALZARINI, Jan M.R.,DE CLERCQ, Erik Desire Alice
申请号：
ES02740215
公开号：
ES2564144T3
申请日:
2002.06.28
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of the formula (I) ** Formula ** in which R 1 is H, amino or methylsulfanyl； R2 is H, methyl, halo, -N (R5) 2, hydroxy, protected hydroxy or a group of the formula (Ia) ** Formula ** R3 is independently H, methyl, hydroxymethyl, halomethyl or protected hydroxymethyl； R4 is H or halo； X is independently oxygen, sulfur or a bond； Z is independently hydroxy, an ester or an amide； R5 is independently H, C1-C8 alkyl or a protecting group； and * designates a chiral carbon atom； and salts and solvates thereof.Un compuesto de la fórmula (I)**Fórmula** en la que R1 es H, amino o metilsulfanilo； R2 es H, metilo, halo, -N(R5)2, hidroxi, hidroxi protegido o un grupo de la fórmula (Ia)**Fórmula** R3 es independientemente H, metilo, hidroximetilo, halometilo o hidroximetilo protegido； R4 es H o halo； X es independientemente oxígeno, azufre o un enlace； Z es independientemente hidroxi, un éster o una amida； R5 es independientemente H, alquilo C1-C8 o un grupo protector； y * designa un átomo de carbono quiral； y sales y solvatos del mismo.
