METCALF, BRIAN,CHUANG, CHIHYUAN,WARRINGTON, JEFFREY,PAULVANNAN, KUMAR,JACOBSON, MATTHEW P.,HUA, LAN,MORGAN, BRADLEY
申请号：
PE0010502014
公开号：
PE24542014A1
申请日:
2012.12.28
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
Referring to a benzaldehyde derivative Compound of formula (i), where q is aryl, heteroaryl, among others and it is or cr1ar1b. A1a is H or Halo Halo r1b is H, and o X is o (CH2) nr8, CH, C (R9) 2 n is 0 OR 1 R8, R9 is H or Oh Halo R2, R3, R4 and R5 are h, Halo, RB, Ord, among others, R6 is a Link R7 is Oh, C1 and C1 C8 alkoxy - haloalcoxi - C8.Preferred compounds are: 2 - (imidazo [1,2-a] pyridin - 8 - ilmetoxi) - 5 - metoxibenzaldehido - formyl - 3, 4 - (imidazo [1,2-a] pyridin - 8 - ilmetoxi) benzonitrile, among others. It also relates to a Preparation Process. These compounds are allosteric modulators of hemoglobinREFERIDA A UN COMPUESTO DERIVADO DE BENZALDEHIDO DE FORMULA (I), DONDE Q ES ARILO, HETEROARILO, ENTRE OTROS Y ES O O CR1aR1b R1a ES H O HALO R1b ES H, HALO Y OH X ES O, CH(CH2)nR8, C(R9)2 n ES 0 O 1 R8 ES OH R9 ES H O HALO R2, R3, R4 Y R5 SON H, HALO, Rb, ORd, ENTRE OTROS R6 ES UN ENLACE R7 ES OH, ALCOXI C1-C8 Y HALOALCOXI C1-C8. SON COMPUESTOS PREFERIDOS: 2-(IMIDAZO[1,2-a]PIRIDIN-8-ILMETOXI)-5-METOXIBENZALDEHIDO, 4-FORMIL-3-(IMIDAZO[1,2-a]PIRIDIN-8-ILMETOXI)BENZONITRILO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UN PROCESO DE PREPARACION. DICHOS COMPUESTOS SON MODULADORES ALOSTERICOS DE HEMOGLOBINA
