The present invention provides a method of treating cancer in a subject afflicted with cancer comprising administering to the subject an anti-clusterin oligonucleotide as a monotherapy to treat the cancer. The present invention also provides compositions for treating cancer in a subject afflicted with cancer, comprising an anti-clusterin oligonucleotide having the sequence CAGCAGCAGAGTCTTCATCAT (Seq. ID No.: 1). Additionally, the present invention provides provides pharmaceutical compositions for treating cancer in a subject afflicted with cancer, the composition comprising an anti-clusterin oligonucleotide having the sequence CAGCAGCAGAGTCTTCATCAT (Seq. ID No.: 1), wherein the anti-clusterin oligonucleotide has a phosphorothioate backbone throughout, has sugar moieties of nucleotides 1-4 and 18-21 bearing 2-O-methoxyethyl modifications, has nucleotides 5-17 which are 2deoxynucleotides, and has 5-methylcytosines at nucleotides 1, 4, and 19.本發明提供一種治療罹患癌症之個體中之癌症的方法,其包含向個體投與抗群集素寡核苷酸作為單一療法以治療癌症。本發明亦提供用於治療罹患癌症之個體中之癌症的組合物,其包含具有序列CAGCAGCAGAGTCTTCATCAT(Seq.ID No.:1)之抗群集素寡核苷酸。另外,本發明提供用於治療罹患癌症之個體中之癌症的醫藥組合物,該組合物包含具有序列CAGCAGCAGAGTCTTCATCAT(Seq.ID No.:1)之抗群集素寡核苷酸,其中該抗群集素寡核苷酸具有貫穿始終的硫代磷酸酯主鏈、具有帶有2-O-甲氧乙基修飾之核苷酸1-4及18-21之糖部分、具有為2去氧核苷酸之核苷酸5-17且在核苷酸1、4及19處具有5-甲基胞嘧啶。
