The present invention relates to a radiation detection sensor, and to an operating method thereof. The radiation detection sensor can accurately measure the coordinates of the position of a target to which radiation is intensively emitted through varying a resistance value or an electric current value of a semiconductor element in a semiconductor matrix. The radiation detection sensor comprises: a first radiation sensor matrix pad including a first semiconductor matrix including a plurality of semiconductor elements and a second radiation sensor matrix pad including a second semiconductor matrix including a plurality of semiconductor elements.COPYRIGHT KIPO 2016본 발명은 반도체 매트릭스 내의 반도체 소자의 저항 값 또는 전류 값 변화를 통하여 방사선이 집중적으로조사되는 표적 위치의 좌표를 정확하게 측정할 수 있는 방사선 감지 센서 및 이의 구동 방법에 관한 것이다.